Effects of Huperzine A in Treatment of Moderate to Severe TBI
Huperzine A, an acetylcholinesterase inhibitor with neuroprotective qualities, is suspected to aid in the improvement of memory functioning in patients who have suffered a traumatic brain injury. This was a randomized, double-blind, placebo-controlled Phase II investigation of the effect of Huperzine A on memory function after moderate to severe TBI as compared to placebo. We explored the effects of Huperzine A on transcranial magnetic stimulation (TMS)-induced neurophysiologic markers, electroencephalography (EEG) event related potentials (P50 and P300), and seizure prevalence. The safety and tolerability of Huperzine A was also examined.
This study was in collaboration with the Spaulding Rehabiliation Hospital Neuromodulation Laboratory and several other Spaulding Rehabilitation Hospital researchers.
The results of this study were published in Brain Injury (Zafonte, et al., 2020).